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You need the correct mask for the job you are doing. You need to know what it is you need to filter.
Here is what I learned by talking to a researcher about the 2k paints with isocyanates.
The charcoal filters will filter out the isocyanates as well as the solvents.
The big problems that happens with the mask type filters is fit and sealing. If you have a leak then you have a problem. That is why positive pressure masks are required on the can.
I STRONGLY recommend a pressure mask if you are spraying modern paints. They are pricey, but the also have very high resale value.
BUT, the number one exposure to iso's is from the skin and not while spraying!
The isocyanates are bad in that they are an illergic reaction. When you become sensitive to them you will (hopefully) feel some chest pressure later. The symptoms will get worse with each exposure. It can give you industrial asthma which has killed some guys.
I like the better qualtiy 3M dust masks for dust work. I have tried cheaper types and they just do not work like the 3M.
Of course, you need to regularly replace the charcoal filters.
Hope that helps.