Yes not too HAMB friendly , how ever you could drop the efi and fit a 4 barrel carb which would simplify the plumbing and wiring . Providing it's not the big modular 4.6 v8.
We fitted one in a 54 ,efi and all , power steer , 4 wheel discs etc ,it wasn't a rocket but a very dependable driver. But when the hood was shut most folk who didn't know thought it was still flathead powered. We used a complete donor car and used everything from the drivetrain.
A couple of links..
http://www.fordtruckfanatics.com/for...ad.php?t=31018
https://www.youtube.com/watch?v=-Mbhxrs3KuQ